|About the Book|
Advances in the treatment of Parkinsons disease (PD) and atypical Parkinsonian disorders (APD) have made it easier for physicians to treat the physical aspects of these diseases. However, it is becoming increasingly evident that more than just theMoreAdvances in the treatment of Parkinsons disease (PD) and atypical Parkinsonian disorders (APD) have made it easier for physicians to treat the physical aspects of these diseases. However, it is becoming increasingly evident that more than just the physical symptoms need to be treated in order to improve overall quality of life (QoL) among PD and APD patients. This study assesses the key factors that influence health-related QoL for both PD and APD patients and compares across the two disease groups as well as among the APD group. Three hundred and fifty three patients were used in this study and diagnosed with having PD (187), PSP (50), MSA (65), DLB (34), or CBD (17). Each patient completed the short form-12 (SF-12), Becks Depression Inventory (BDI), Unified Parkinsons Disease Rating Scale (UPDRS), Mini-Mental State Examination (MMSE), Schwab and England (SE) and the Hoehn and Yahr rating scale (HY) which measured for QoL, depression, mood, behavior, motor functioning, activities of daily living, cognitive function and disease severity. We also looked at age and gender identification. After analyzing the results, APD patients were found to have overall lower health-related QoL than PD patients in earlier age groups when comparing SF-12 PCS scores. MCS scores between PD and APD were not significantly different. In addition, no significant differences were found between SF-12 scores when comparing PSP, MSA, CBD and DLB. Depression was found to be the main determinant of health-related QoL among all disease groups, and was a stronger predictor of QoL for PD than APD. Mood, behavior and mentation were predictors of QoL for PD and DLB. Motor functioning, age and gender were significant determinants of QoL only for PD, while disease severity was a determining factor for MSA and CBD patients. In addition, activities of daily living was a predictor of QoL for PD, DLB, and PSP. This study shows that various factors affect health-related QoL differently among different disease groups and should be taken into consideration by physicians in order to provide the best medical care possible.