Home » Host Genes and HIV: The Role of the Chemokine Receptor Gene CCR5 and Its Allele (D32 CCR5) by Janet M. McNicholl
Host Genes and HIV: The Role of the Chemokine Receptor Gene CCR5 and Its Allele (D32 CCR5) Janet M. McNicholl

Host Genes and HIV: The Role of the Chemokine Receptor Gene CCR5 and Its Allele (D32 CCR5)

Janet M. McNicholl

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Kindle Edition
29 pages
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 About the Book 

Since the late 1970s, 8.4 million people worldwide, including 1.7 million children,have died of AIDS, and an estimated 22 million people are infected with humanimmunodeficiency virus (HIV)(1). During 1995 and 1996, major clinical and laboratoryMoreSince the late 1970s, 8.4 million people worldwide, including 1.7 million children,have died of AIDS, and an estimated 22 million people are infected with humanimmunodeficiency virus (HIV)(1). During 1995 and 1996, major clinical and laboratorydiscoveries regarding HIV pathogenesis provided new hope for the prevention andtreatment of HIV infection. One major discovery was that members of the chemokinereceptor family serve as cofactors for HIV entry into cells. We describe the role of allelicpolymorphism in the gene coding for the CCR5 chemokine receptor with regard tosusceptibility to and disease course of HIV infection. We also examine the effect of thisdiscovery on medical and public health practices.